Distributing drugs through lungs – inflammation ?
April 26th, 2008 Posted in Nanomedicine NEWS
Many nanoscientists consider distributing drugs through lungs has a big potential and could be the best route to get drugs to certain organs. However, studies have shown that nanoparticles can trigger inflammation in lungs after inhaling them. These studies can be alleviated thanks to new findings that nanoparticles which are made out of biodegradable materials do NOT trigger an inflammation. The research was based on biostable polystyrene, PLGA, and a novel polymer formed out of PLGA and PVA. The latter is considered very important in pulmonary delivery of pharmaceuticals. PLGA-PVA did not trigger any inflammation, but were killed by macrophages more quickly – which is not desirable for a drug delivery vehicle.
